Basicity of Amines And pKaH
Quantifying The Basicity Of Amines, Using “The pKa Of The Conjugate Acid”, a.k.a. “pKaH” How do you measure the basicity of an amine? Case in point:
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5 Key Basicity Trends of Amines
5 Key Amine Basicity Trends What are the most important factors that affect the basicity of amines? Here are 5 key trends. Basicity increases with
Read moreNucleophilicity of Amines
Nucleophilicity Of Amines The relative nucleophilicity of amines doesn’t get a lot of coverage in many organic chemistry courses, but if we’re going to cover
Read moreAlkylation of Amines (Sucks!)
Why Alkylation Of Amines (aka “The Williamson Ether Synthesis, But For Amines” ) Usually Doesn’t Pan Out Making a more-substituted amine from a less-substituted amine
Read moreThe Hofmann Elimination
The Hofmann Elimination Of Alkylammonium Salts: Examples and Mechanism The Hofmann Elimination is an elimination reaction of alkylammonium salts that forms C-C double bonds [pi
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