Weirdest spam comment I’ve had in awhile

March 23, 2015

In the “WTF” category…   Author : Dr abdoul E-mail : cleaninglabyahoocom URL : http://www.cleaninglab.ga Comment: WELCOME TO CLEANINGLAB LABORATORIES (PTY) LTD. WE PROVIDE SSD SOLUTION CHEMICAL FOR CLEANING BLACK MONEY HI,THIS IS JUST TO INFORM YOU THAT OUR COMPANY CAN CLEAN OUT BLACK MONEY CALLED ANTI-BREEZE (STAINED MONEY) BANK NOTES SO PLEASE IF YOU […]

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PBr3 and SOCl2

March 20, 2015

Lately we’ve been talking a lot about converting alcohols to good leaving groups [halides] [tosylates and mesylates] You might think we’d be done already, but not yet! In today’s post we talk about a third important method for converting alcohols to good leaving groups – by using the reagents phosphorus tribromide (PBr3) and thionyl chloride […]

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Tosylates And Mesylates

March 10, 2015

Today we’re going to talk about a different way of making alcohols into good leaving groups – by turning them into tosylates and mesylates (“organosulfonates”). Here’s a brief summary of what we’ll cover here: Making Alcohols Into Good Leaving Groups, Part 2 We’ve seen that alcohols are poor substrates for substitution reactions. The main problem is that […]

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Making Alkyl Halides From Alcohols

February 27, 2015

Making Alkyl Halides From Alcohols In today’s post we show that treating alcohols with HCl, HBr, or HI (which all fall under the catch-all term “HX” where X is a halide) results in the formation of alkyl halides. We’ve said many times in this series of posts that alcohols are poor substrates for SN1 and SN2 […]

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The Organic Chemistry Behind “The Pill”

February 13, 2015

The Most Interesting Man In The World passed away the other week. No, not THAT guy. He’s just an actor. The OTHER guy. The OTHER guy is Carl Djerassi, organic chemist, professor, author, playwright, and most notably, “Father of the Pill”. Lots of people these days – especially startups –  talk about changing the world. […]

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Opening Of Epoxide With Base

February 10, 2015

Opening of epoxides with base a summary of what we talk about today: In the last post we discussed the reactions of epoxides under acidic conditions and saw how they resembled the “3-membered ring” family of alkene mechanisms. We left off by noting that the reaction of the epoxide (shown above)  with NaOH in H2O […]

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Opening of Epoxides With Acid

February 2, 2015

Here’s what we’re covering in this post. Opening Epoxides With Aqueous Acid In the last post, we saw some examples of how epoxides are considerably more reactive towards breakage than are ordinary ethers. For example, aqueous acid [often abbreviated “H3O+”] will open an epoxide under MUCH milder conditions than an “ordinary” ether such as diethyl […]

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Epoxides – The Outlier Of The Ether Family

Epoxides – The Outlier Of The Ether Family

January 26, 2015

 In this post we discuss a special class of ethers that has unusually high reactivity due to their ring strain – epoxides. Here’s a summary of what we’ll talk about here:   In the last post, I wrote that ethers were quite possibly the most boring functional group of all, at least from the perspective of reactivity. […]

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Chiral Allenes And Chiral Axes

Chiral Allenes And Chiral Axes

January 13, 2015

We’ve met alkenes before – right? Just in case you haven’t, let’s review the basics, because today’s post is going to depend on understanding a few of the most important concepts. Alkenes contain both sigma [ σ]  bonding formed through “head-on” orbital overlap [i.e. “single bonds”] and also pi [ π ] bonding where orbitals have […]

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My Recent Absence, Explained With 9 Molecules

My Recent Absence, Explained With 9 Molecules

January 6, 2015

Hey folks – it’s been awhile! Let me explain. It all started very innocently. In mid November I started noticing that a little bump I’d had on the back of my neck for what seemed like forever had started getting sore. At first it was annoying. One Wednesday night I was taking a fencing lesson, […]

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