Basicity of Amines And pKaH
Quantifying The Basicity Of Amines, Using “The pKa Of The Conjugate Acid”, a.k.a. “pKaH” How do you measure the basicity of an amine? Case in point:
Read moreQuantifying The Basicity Of Amines, Using “The pKa Of The Conjugate Acid”, a.k.a. “pKaH” How do you measure the basicity of an amine? Case in point:
Read moreReactions of Grignard Reagents With Water, Carboxylic Acids, And Other Mildly Acidic Species Last post we talked about how to make certain organometallics, specifically Grignard
Read moreAlcohols: The Conjugate Acid Is A Better Leaving Group, and The Conjugate Base Is A Better Nucleophile In the last post we explored some of the properties and
Read moreAcid-Base Reactions Of Alcohols Alcohols are mild acids. Typical aliphatic (i.e. “alkyl”) alcohols such as ethanol, isopropanol, and t-butanol have a pKa of about 16-18, making
Read moreThe Important Role of The Counter-Ion In Determining E1 vs SN1 E1 will generally be favored over SN1 when heat is applied Secondly, in E1
Read moreAdding Acid Increases Leaving Group Ability Sure, it’s one thing to recognize halogens (Cl, Br, and I) as having high leaving group ability, as well
Read moreBasicity In Organic Chemistry: Some Basicity Trends Today we’ll look at a simple periodic basicity trend across the periodic table and extrapolate from it some
Read moreFive Key Factors That Affect Acidity Today we’ll talk about what’s behind the trends in acidity for different molecules and discuss the most important factors
Read moreToday we’ll talk about an incredibly important skill that might take some time to grasp but pays tremendous dividends. We’ll go through the exact details of how to use a pKa table. Understanding the proper use of a pKa table will give you the ability to recognize which acid-base reactions will happen and which will not. This will come up a lot as you progress through Org 1 and Org 2. It might be helpful to go back and review some of the factors that affect acidity that were talked about earlier.
Read moreThe importance of pKa values in organic chemistry can’t be overestimated, in my opinion. Not knowing pKa values in organic chemistry is like not knowing
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