Comparing the SN1 and SN2 Reactions
Comparing the SN1 and SN2 Reactions In nucleophilic substitution reactions, a bond between carbon and a leaving group (C–LG) is broken, and a new bond
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What Makes A Good Nucleophile?
Factors That Determine Whether A Species Is A Good Nucleophile If you read the last post, you’ll recall that a nucleophile is a species that
Read moreWhat Makes A Good Leaving Group?
Good Leaving Groups Are Weak Bases A leaving group (a.k.a. “nucleofuge”) is the new Lewis base that is generated in various substitution and elimination reactions when
Read moreSteric Hindrance is Like a Fat Goalie
Steric Hindrance In Nucleophilic Substitution Reactions Sportswriter Todd Gallagher asked a question that every hockey fan has probably asked at one point. “Could a morbidly
Read moreReagent Friday: TsCl (p-toluenesulfonyl chloride) and MsCl (methanesulfonyl chloride)
TsCl (p-toluenesulfonyl chloride) And MsCl (methanesulfonylchloride) As Reagents In Organic Chemistry In a blatant plug for the Reagent Guide, each Friday I profile a different reagent
Read moreGrossman’s Rule
A few months ago after putting up this post on “Hidden Hydrogens, Hidden Lone Pairs, and Hidden Counterions”, commenter Stewie Griffin made me aware of
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