What’s An Organometallic?
What Is The Definition of An Organometallic Compound? In many of the functional groups in organic chemistry, carbon is attached to a more electronegative element,
Read moreOrganometallics
Formation of Grignard and Organolithium Reagents
Formation or Grignard Reagents and Organolithium Reagents From Alkyl and Alkenyl Halides In the last post we introduced the concept of organometallic compounds – molecules
Read moreOrganometallics Are Strong Bases
Reactions of Grignard Reagents With Water, Carboxylic Acids, And Other Mildly Acidic Species Last post we talked about how to make certain organometallics, specifically Grignard
Read moreReactions of Grignard Reagents
All About The Reactions of Grignard Reagents Grignard reagents are excellent carbon-based nucleophiles as well as strong bases. They will add to aldehydes and ketones
Read moreProtecting Groups In Grignard Reactions
Using Protecting Groups In The Formation of Grignard Reagents Now that we’ve gone over the most useful reactions of Grignard reagents – addition to epoxides,
Read moreSynthesis Problems Involving Grignard Reagents
Grignard Practice Problems: Synthesis Exercises Involving Grignard Reagents Grignard reagents add once to aldehydes to give secondary alcohols and also add once to ketones to give tertiary
Read moreGrignard Reactions And Synthesis (2)
More Grignard Practice Problems, This Time Incorporating Oxidation Here’s the summary for today’s post on synthesis incorporating Grignard reagents and oxidants. Converting an aldehyde into
Read moreOrganocuprates (Gilman Reagents): How They’re Made
How Gilman Reagents (Organocuprates) Are Made Gilman reagents (organocuprates, often written as “R2CuLi” are not made the same way as Grignard or organolithium reagents. Instead of
Read moreGilman Reagents (Organocuprates): What They’re Used For
So What Are Gilman Reagents Used For, Anyway? Last time we talked about how to make Gilman reagents (organocuprates). In this post, we’ll talk about
Read moreThe Heck, Suzuki, and Olefin Metathesis Reactions (And Why They Don’t Belong In Most Introductory Organic Chemistry Courses)
The Heck, Suzuki, and Olefin Metathesis Reactions Are Really Cool. [But They Don’t Belong In (Most) Introductory Courses] There has been a trend in recent
Read more