Grignards

Opening Of Epoxide With Base

Opening Of Epoxide With Base

February 10, 2015

Opening of epoxides with base a summary of what we talk about today: In the last post we discussed the reactions of epoxides under acidic conditions and saw how they resembled the “3-membered ring” family of alkene mechanisms. We left off by noting that the reaction of the epoxide (shown above)  with NaOH in H2O […]

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Common Mistakes with Carbonyls: Carboxylic Acids… Are Acids!

May 20, 2011

Carboxylic acids… are acids. I know that seems obvious. But it’s a near certainty that students taking Org 2 for the first time will forget this occasionally. Here are two common mistakes that I see *all the time*. 1) Reactions of Grignard reagents with carboxylic acids. Grignard reagents (with the general structure RMgBr) are great […]

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