Basicity of Amines And pKaH
Quantifying The Basicity Of Amines, Using “The pKa Of The Conjugate Acid”, a.k.a. “pKaH” How do you measure the basicity of an amine? Case in point:
Read moreconjugate base
5 Key Basicity Trends of Amines
5 Key Amine Basicity Trends What are the most important factors that affect the basicity of amines? Here are 5 key trends. Basicity increases with
Read moreOrganometallics Are Strong Bases
Reactions of Grignard Reagents With Water, Carboxylic Acids, And Other Mildly Acidic Species Last post we talked about how to make certain organometallics, specifically Grignard
Read moreAlcohols Can Act As Acids Or Bases (And Why It Matters)
Alcohols: The Conjugate Acid Is A Better Leaving Group, and The Conjugate Base Is A Better Nucleophile In the last post we explored some of the properties and
Read moreAlcohols – Acidity and Basicity
Acid-Base Reactions Of Alcohols Alcohols are mild acids. Typical aliphatic (i.e. “alkyl”) alcohols such as ethanol, isopropanol, and t-butanol have a pKa of about 16-18, making
Read moreThe Conjugate Acid Is A Better Leaving Group
Adding Acid Increases Leaving Group Ability Sure, it’s one thing to recognize halogens (Cl, Br, and I) as having high leaving group ability, as well
Read moreAcid Base Reactions In Organic Chemistry
An Introduction to Acid Base Reactions In Organic Chemistry Now that we’ve described how to figure out where the electrons are in a molecule, the
Read moreFive Key Factors That Influence Acidity
Five Key Factors That Affect Acidity Today we’ll talk about five key factors that determine acidity for different molecules and a mnemonic (ARIO, or CARDIO)
Read moreFactors That Affect Base Strength In Organic Chemistry
Basicity In Organic Chemistry: Some Basicity Trends In this article we go through some important basicity trends in organic chemistry. (Previous article – Acidity Trends) The
Read moreHow to Use a pKa Table
Today we’ll talk about an incredibly important skill that might take some time to grasp but pays tremendous dividends. We’ll go through the exact details of how to use a pKa table. Understanding the proper use of a pKa table will give you the ability to recognize which acid-base reactions will happen and which will not. This will come up a lot as you progress through Org 1 and Org 2. It might be helpful to go back and review some of the factors that affect acidity that were talked about earlier.
Read more