The pKa Table Is Your Friend
The importance of pKa values in organic chemistry can’t be overestimated, in my opinion. Not knowing pKa values in organic chemistry is like not knowing
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What Makes A Good Leaving Group?
Good Leaving Groups Are Weak Bases A leaving group (a.k.a. “nucleofuge”) is the new Lewis base that is generated in various substitution and elimination reactions when
Read moreA Handy Rule of Thumb for Acid-Base Reactions
Reversible And Irreversible Acid-Base Reactions Last time we learned about pKa and how it’s the closest thing we have to a universal measurement of the
Read moreAcid Base Reactions Are Fast
Acid-Base Reactions Are Generally Faster Than Substitution Or Addition Reactions Here is a very common dilemma in organic chemistry as you move through the latter parts
Read moreHow Protonation and Deprotonation Affect Reactivity
Protonation and Deprotonation: How They Affect Reactivity One thing has been missing from our discussion of acid-base reactions. Who cares? What does it matter that
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