The Michael Addition Reaction and Conjugate Addition
The Michael Addition Reaction (and Conjugate Addition) The Michael reaction (sometimes “Michael Addition”) is the addition of an enolate to an electrophilic alkene, such as
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What’s An Organometallic?
What Is The Definition of An Organometallic Compound? In many of the functional groups in organic chemistry, carbon is attached to a more electronegative element,
Read moreOrganometallics Are Strong Bases
Reactions of Grignard Reagents With Water, Carboxylic Acids, And Other Mildly Acidic Species Last post we talked about how to make certain organometallics, specifically Grignard
Read moreReactions of Grignard Reagents
All About The Reactions of Grignard Reagents Grignard reagents are excellent carbon-based nucleophiles as well as strong bases. They will add to aldehydes and ketones
Read moreSynthesis Problems Involving Grignard Reagents
Grignard Practice Problems: Synthesis Exercises Involving Grignard Reagents Grignard reagents add once to aldehydes to give secondary alcohols and also add once to ketones to give tertiary
Read moreGilman Reagents (Organocuprates): What They’re Used For
So What Are Gilman Reagents Used For, Anyway? Last time we talked about how to make Gilman reagents (organocuprates). In this post, we’ll talk about
Read moreEpoxide Ring Opening With Base
Ring-opening of epoxides with basic nucleophiles Epoxides are cyclic ethers with considerable ring strain (about 13 kcal/mol) Epoxides undergo reaction with nucleophiles under basic conditions
Read moreCommon Mistakes with Carbonyls: Carboxylic Acids… Are Acids!
Carboxylic acids… are acids. I know that seems obvious. But it’s a near certainty that students taking Org 2 for the first time will forget
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