Deciding SN1/SN2/E1/E2 – The Solvent
Secondary Alkyl Halides With Strongly Basic Nucleophiles. The “Ask Your Instructor” Edition In the previous four articles in this series, we covered how to identify where
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Wrapup: The Key Factors For Determining SN1/SN2/E1/E2
SN1/SN2/E1/E2 – Summarizing The Key Factors That Determine Whether A Reaction Will Be SN1, SN2, E1 or E2 In this article we walk through the
Read moreAlkyl Halide Reaction Map And Summary
Alkyl Halide Reaction Map In the last post, we began our discussion of synthesis by starting with the reactions of alkanes. Since we’ve learned only
Read moreElimination Reactions (2): The Zaitsev Rule
Elimination Reactions: The Zaitsev Rule Elimination reactions usually occur such that they are removing a hydrogen from the carbon attached to the fewest hydrogens. This
Read moreElimination Reactions Are Favored By Heat
Elimination Reactions Are Favored By Heat Elimination reactions are often in competition with substitution reactions Generally speaking, adding heat tends to increase the proportion of elimination products relative
Read moreTwo Elimination Reaction Patterns
A Tale of Two Elimination Reaction Patterns Like I said in the introduction to substitution reactions, organic chemistry is an empirical, experimental science. We make
Read moreCarbocation Rearrangement Reactions (2) – Alkyl Shifts
Alkyl Shifts In Carbocation Rearrangement Reactions, Including Ring Expansion Hydride shifts can sometimes occur when a more stable carbocation can be formed through migration of
Read moreNucleophilic Substitution Reactions – Introduction
Introduction to Nucleophilic Substitution Reactions Today starts a new series of posts on walking through one of the key classes of reaction in organic chemistry:
Read moreTwo Types of Nucleophilic Substitution Reactions
Comparing Two Nucleophilic Substitution Reactions That Clearly Have Different Mechanisms Experiments tell us that nucleophilic substitution reactions generally fall into two main groups: In one group: The reaction
Read moreThe SN2 Mechanism
The SN2 Reaction Mechanism Having gone through the two different types of substitution reactions, and talked about nucleophiles and electrophiles, we’re finally in a position
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