Deciding SN1/SN2/E1/E2: The Solvent
Secondary Alkyl Halides With Strongly Basic Nucleophiles. The “Ask Your Instructor” Edition In the previous four articles in this series, we covered how to identify where
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Wrapup: The Key Factors For Determining SN1/SN2/E1/E2
SN1/SN2/E1/E2 – Summarizing The Key Factors That Determine Whether A Reaction Will Be SN1, SN2, E1 or E2 In this article we walk through the
Read moreTwo Elimination Reaction Patterns
A Tale of Two Elimination Reaction Patterns Like I said in the introduction to substitution reactions, organic chemistry is an empirical, experimental science. We make
Read moreThe E2 Mechanism
E2 Mechanism – How The E2 (Elimination, Biomolecular) Reaction Works Having gone through the E1 mechanism for elimination reactions, we’ve accounted for one way in
Read moreE1 vs E2: Comparing the E1 and E2 Reactions
E1 versus E2 : Comparing The E1 and E2 Reactions Now that we’ve gone through the mechanisms of the E1 and E2 reactions, let’s take
Read moreAntiperiplanar Relationships: The E2 Reaction and Cyclohexane Rings
Antiperiplanar Relationships Between C-H And The Leaving Group: The E2 Reaction and Cyclohexane Rings Here we come to a very testable application of the E2 reaction
Read moreBulky Bases in Elimination Reactions
Elimination Reactions Using “Bulky Bases” – When The Zaitsev Product Is Minor We’ve recently talked about Zaitsev’s rule in elimination reactions, and how the transition
Read moreComparing the E1 vs SN1 Reactions
The Important Role of The Counter-Ion In Determining E1 vs SN1 With tertiary alkyl halides, E1 will generally be favored over SN1 when heat is
Read moreE1cB: Elimination (Unimolecular) Conjugate Base
The E1cB (E1, Conjugate Base) Elimination Mechanism The E1cB (Elimination, Unimolecular, Conjugate Base) mechanism is a third mechanistic pathway for elimination reactions. In many ways
Read moreLevels of Mastery
Here’s an idea I’ve been playing with: levels of mastery. Growing up with video games, it’s an idea that is intuitively familiar, but not often
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