Electrophilic Aromatic Substitution: Introduction
The Six Key Electrophilic Aromatic Substitution Reactions In electrophilic aromatic substitution a C-H bond is broken and a new C-E bond (E being an electrophilic
Read moreFriedel-Crafts
EAS Reactions (3) – Friedel-Crafts Acylation and Friedel-Crafts Alkylation
Friedel Crafts Alkylation and Acylation Aromatic rings will form C-C bonds when treated with alkyl or acyl halides in the presence of a strong Lewis
Read moreIntramolecular Friedel-Crafts Reactions
The Intramolecular Friedel-Crafts Reaction We explore the intramolecular Friedel-Crafts reaction in this post. But first, a very quick refresher on intramolecular reactions in general. Table
Read moreThe Wolff-Kishner, Clemmensen, And Other Carbonyl Reductions
The Wolff-Kishner, Clemmensen, and Other Fun Reductions In this post we go through 4 ways of reducing C=O to CH2 including: The Wolff-Kishner reaction The
Read moreAromatic Synthesis (1) – “Order Of Operations”
Planning An Aromatic Synthesis: Putting Reactions In The Right Order When planning a synthesis of simple aromatic compounds, it’s not enough to pick the right
Read moreSynthesis of Benzene Derivatives (2) – Polarity Reversal
Synthesis of Benzene Derivatives: Converting ortho-,para- directors into meta- directors and vice versa. In planning the synthesis of simple benzene derivatives and other aromatic compounds,
Read moreThe Lies We Tell
Zed Shaw teaches a course in writing Python called “Python the Hard Way“. Because the hard way is easier, he says. In the end, he’s
Read moreCommon Blind Spot: Intramolecular Reactions
Intramolecular Reactions An intramolecular reaction is when the nucleophile and electrophile are present on the same molecule. The bonds that form and break in an
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