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alcohols

Alcohols – Acidity and Basicity

Acid-Base Reactions Of Alcohols Alcohols are mild acids.  Typical aliphatic (i.e. “alkyl”) alcohols such as ethanol, isopropanol, and t-butanol have a pKa of about 16-18, making

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Cleavage Of Ethers With Acid

Acidic Cleavage of Ethers Can Proceed Through an SN2 or SN1 Mechanism, Depending On The Structure Ethers do not undergo very many reactions. One key

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Epoxide Ring Opening With Base

Ring-opening of epoxides with basic nucleophiles Epoxides are cyclic ethers with considerable ring strain (about 13 kcal/mol) Epoxides undergo reaction with nucleophiles under basic conditions

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PBr3 and SOCl2

PBr3 and SOCl2: Reagents For Converting Alcohols To Good Leaving Groups Alcohols can be converted into alkyl halides with phosphorus tribromide (PBr3) or thionyl chloride

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Protecting Groups For Alcohols

Alcohol Protecting Groups There are many times when it’s useful to mask the reactivity of alcohols since their relatively high acidity interferes with strongly basic

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