The E2 Mechanism
E2 Mechanism – How The E2 (Elimination, Biomolecular) Reaction Works Having gone through the E1 mechanism for elimination reactions, we’ve accounted for one way in
Read moreE1 vs E2: Comparing the E1 and E2 Reactions
E1 versus E2 : Comparing The E1 and E2 Reactions Now that we’ve gone through the mechanisms of the E1 and E2 reactions, let’s take
Read moreAntiperiplanar Relationships: The E2 Reaction and Cyclohexane Rings
Antiperiplanar Relationships Between C-H And The Leaving Group: The E2 Reaction and Cyclohexane Rings Here we come to a very testable application of the E2 reaction
Read moreBulky Bases in Elimination Reactions
Elimination Reactions Using “Bulky Bases” – When The Zaitsev Product Is Minor We’ve recently talked about Zaitsev’s rule in elimination reactions, and how the transition
Read moreComparing the E1 vs SN1 Reactions
The Important Role of The Counter-Ion In Determining E1 vs SN1 With tertiary alckyl halides, E1 will generally be favored over SN1 when heat is
Read moreElimination (E1) Reactions With Rearrangements
Elimination Reactions (E1) That Occur With Rearrangements – Hydride Or Alkyl Shifts Where there are carbocations (see last post), rearrangement reactions are never far behind.
Read moreE1cB – Elimination (Unimolecular) Conjugate Base
The E1cB (E1, Conjugate Base) Elimination Mechanism The E1cB (Elimination, Unimolecular, Conjugate Base) mechanism is a third mechanistic pathway for elimination reactions. In many ways
Read moreCarbocation Rearrangement Reactions (2) – Alkyl Shifts
Alkyl Shifts In Carbocation Rearrangement Reactions, Including Ring Expansion Hydride shifts can sometimes occur when a more stable carbocation can be formed through migration of
Read moreFunctional Groups Summary Sheet
Functional Groups Summary Sheet I thought it would be good to make a summary sheet based on functional groups, so here one is: Functional Group
Read morePinacol Rearrangement
The Pinacol Rearrangement The pinacol rearrangement is an acid-catalyzed rearrangement of 1,2-diols (vicinal diols) The acid serves to protonate one of the hydroxyl groups, which
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