Bowing to pressure from consumer products companies facing a growing public relations nightmare over chemical ingredients in food, the International Union of Pure and Applied
Read moreHow to obtain a pure compound from a crude mixture: 5 Key Purification Techniques Previously, we showed a few examples of preparing crude extracts from plants
Read moreToday I’m delighted to announce a new book – Practice Organic Mechanisms, co-written with Dr. Michelle Sulikowski, Senior Lecturer of Organic Chemistry at Vanderbilt University. Practice Organic
Read moreFormation or Grignard Reagents and Organolithium Reagents From Alkyl and Alkenyl Halides In the last post we introduced the concept of organometallic compounds – molecules
Read moreReactions of Grignard Reagents With Water, Carboxylic Acids, And Other Mildly Acidic Species Last post we talked about how to make certain organometallics, specifically Grignard
Read moreAll About The Reactions of Grignard Reagents Grignard reagents are excellent carbon-based nucleophiles as well as strong bases. They will add to aldehydes and ketones
Read moreUsing Protecting Groups In The Formation of Grignard Reagents Now that we’ve gone over the most useful reactions of Grignard reagents – addition to epoxides,
Read moreGrignard Practice Problems: Synthesis Exercises Involving Grignard Reagents Grignard reagents add once to aldehydes to give secondary alcohols and also add once to ketones to give tertiary
Read moreMore Grignard Practice Problems, This Time Incorporating Oxidation Here’s the summary for today’s post on synthesis incorporating Grignard reagents and oxidants. Converting an aldehyde into
Read moreHow Gilman Reagents (Organocuprates) Are Made Gilman reagents (organocuprates, often written as “R2CuLi” are not made the same way as Grignard or organolithium reagents. Instead of
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