On Cats, Part 1: Conformations and Configurations
[NOTE: this has been amended to correct some confusion on my part on the difference between configurational and constitutional isocats. Thanks to Prof. Gary Weisman
Read moreWhat’s An Organometallic?
What Is The Definition of An Organometallic Compound? In many of the functional groups in organic chemistry, carbon is attached to a more electronegative element,
Read moreNew IUPAC Rules Make Molecular Names More Pronounceable, Friendlier
Bowing to pressure from consumer products companies facing a growing public relations nightmare over chemical ingredients in food, the International Union of Pure and Applied
Read moreNatural Product Isolation (2): Purification Techniques, An Overview
How to obtain a pure compound from a crude mixture: 5 Key Purification Techniques Previously, we showed a few examples of preparing crude extracts from plants
Read moreOur New Book, “Practice Organic Mechanisms”, Is Out
Today I’m delighted to announce a new book – Practice Organic Mechanisms, co-written with Dr. Michelle Sulikowski, Senior Lecturer of Organic Chemistry at Vanderbilt University. Practice Organic
Read moreFormation of Grignard and Organolithium Reagents
Formation or Grignard Reagents and Organolithium Reagents From Alkyl and Alkenyl Halides In the last post we introduced the concept of organometallic compounds – molecules
Read moreOrganometallics Are Strong Bases
Reactions of Grignard Reagents With Water, Carboxylic Acids, And Other Mildly Acidic Species Last post we talked about how to make certain organometallics, specifically Grignard
Read moreReactions of Grignard Reagents
All About The Reactions of Grignard Reagents Grignard reagents are excellent carbon-based nucleophiles as well as strong bases. They will add to aldehydes and ketones
Read moreProtecting Groups In Grignard Reactions
Using Protecting Groups In The Formation of Grignard Reagents Now that we’ve gone over the most useful reactions of Grignard reagents – addition to epoxides,
Read moreSynthesis Problems Involving Grignard Reagents
Grignard Practice Problems: Synthesis Exercises Involving Grignard Reagents Grignard reagents add once to aldehydes to give secondary alcohols and also add once to ketones to give tertiary
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