Nucleophilic Acyl Substitution (With Negatively Charged Nucleophiles) Yes, there are a lot of reactions of carboxylic acid derivatives to learn! In this article we’ll explore
Read moreQuantifying The Basicity Of Amines, Using “The pKa Of The Conjugate Acid”, a.k.a. “pKaH” How do you measure the basicity of an amine? Case in point:
Read more5 Key Amine Basicity Trends What are the most important factors that affect the basicity of amines? Here are 5 key trends. Basicity increases with
Read moreA Puzzle In The Basicity Of Some Disubstituted Aromatic Amines We’ve seen that several key factors influence the basicity of amines – charge, resonance, inductive
Read moreNucleophilicity Of Amines The relative nucleophilicity of amines doesn’t get a lot of coverage in many organic chemistry courses, but if we’re going to cover
Read moreCarboxylic acids… are acids. I know that seems obvious. But it’s a near certainty that students taking Org 2 for the first time will forget
Read moreAn Introduction to Acid Base Reactions In Organic Chemistry Now that we’ve described how to figure out where the electrons are in a molecule, the
Read moreFive Key Factors That Affect Acidity Today we’ll talk about five key factors that determine acidity for different molecules and a mnemonic (ARIO, or CARDIO)
Read moreBasicity In Organic Chemistry: Some Basicity Trends In this article we go through some important basicity trends in organic chemistry. (Previous article – Acidity Trends) The
Read moreThe Acidity Constant Ka (And Its Negative Logarithm pKa ) Is An Extremely Useful Measure Of Acidity So last time we went through all the
Read more