Reactions of Dienes: 1,2 and 1,4 Addition
Kinetic Versus Thermodynamic Control In Addition of HBr to Dienes: 1,2- and 1,4- Addition In today’s post we’ll discuss 1,2- and 1,4- addition to dienes
Read moreReductive Amination
Making Substituted Amines Through Reductive Amination Direct alkylation of amines with alkyl halides is a difficult reaction to control. One alternative that works extremely well
Read moreNucleophilic Aromatic Substitution (2) – The Benzyne Mechanism
In this article we’ll discuss nucleophilic aromatic substitution, but with a new twist; a nucleophilic aromatic substitution that passes through a strange-looking intermediate called an
Read moreWhat is Mutarotation?
All About Mutarotation The OH group on C-1 of sugars can have two possible configurations. This gives rise to two stereoisomers (called “anomers”) : the
Read moreReactions on the Benzylic Carbon: Bromination And Oxidation
The carbon adjacent to an aromatic ring – the “benzylic” carbon – can participate in several useful and interesting reactions. Today we’ll provide examples and
Read moreThermodynamic and Kinetic Products
Thermodynamic vs Kinetic Products In Purchasing Decisions (And Addition To Dienes) A post about getting what you pay for, and how that translates to “kinetic
Read moreThe Wolff-Kishner, Clemmensen, And Other Carbonyl Reductions
The Wolff-Kishner, Clemmensen, and Other Fun Reductions In this post we go through 4 ways of reducing C=O to CH2 including: The Wolff-Kishner reaction The
Read moreThe Gabriel Synthesis
The Gabriel Synthesis For Making Primary Amines We’ve seen previously that it’s hard to *usefully* build amines through the SN2 reaction, because once amines start
Read moreMore Reactions on the Aromatic Sidechain: Reduction of Nitro Groups and the Baeyer Villiger
Here we cover three new reactions of aromatic substituents: reduction of nitro groups to amines, protection of amines as amides, and the Baeyer-Villiger oxidation of
Read moreMore On 1,2 and 1,4 Additions To Dienes
Two More Diene Reactions: Free-Radical Addition of HBr to Dienes, and Addition of Br2 to Dienes In an earlier post we covered 1,2 and 1,4
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