Aromatic Reactions

Reactions on the “Benzylic” Carbon: Bromination And Oxidation

Reactions on the “Benzylic” Carbon: Bromination And Oxidation

June 13, 2018

Today we’ll be going through two reactions on alkyl groups adjacent to aromatic rings: benzylic bromination and benzylic oxidation. Here’s the quick summary: Alkyl Groups = Roughage In nutrition, “ro…

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Intramolecular Friedel-Crafts Reactions

Intramolecular Friedel-Crafts Reactions

May 30, 2018

Intramolecular Reactions Here is an instant formula for an organic chemistry exam question. Start with a straightforward reaction that students understand fairly well,  like the Williamson Ether synthesis…. (dr…

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Electrophilic Aromatic Substitution Reactions (3) – Friedel Crafts Alkylation and Acylation

Electrophilic Aromatic Substitution Reactions (3) – Friedel Crafts Alkylation and Acylation

May 17, 2018

Today’s post is on the Friedel-Crafts alkylation and acylation reactions. Quick summary: This is the third in a series of three posts on the key electrophilic aromatic substitution (EAS) reactions in introductor…

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Electrophilic Aromatic Substitutions (2) – Nitration and Sulfonylation

Electrophilic Aromatic Substitutions (2) – Nitration and Sulfonylation

April 30, 2018

Today’s topic: nitration and sulfonylation of benzene: In the previous post on halogenation via electrophilic aromatic substitution, we saw that this electrophilic aromatic substitution reaction proceeded in thr…

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Electrophilic Aromatic Substitutions (1) – Halogenation

Electrophilic Aromatic Substitutions (1) – Halogenation

April 18, 2018

Now that we’ve spent ample time digging into the mechanism of electrophilic aromatic substitution,  activating and deactivating groups, and ortho- ,para– and meta– directors, we’re finally rea…

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Disubstituted Benzenes: The Strongest Electron-Donor “Wins”

Disubstituted Benzenes: The Strongest Electron-Donor “Wins”

March 19, 2018

Having gone through the mechanism of electrophilic aromatic substitution, explored activating and deactivating substituents, and seen the importance of directing groups, let’s now take the opportunity to use t…

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Why are halogens ortho- para- directors?

March 5, 2018

The previous post in this series tried to show that the key to understanding why a substituent is an ortho-, para- director or meta– director lies in understanding how it influences the stability of the ort…

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Understanding Ortho, Para, and Meta Directors

Understanding Ortho, Para, and Meta Directors

February 2, 2018

In the previous post we introduced ortho- ,para- and meta- directors in electrophilic aromatic substitution.  Previous to that we covered the mechanism of electrophilic aromatic substitution, and showed that the mec…

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Ortho-, Para- and Meta- Directors in Electrophilic Aromatic Substitution

January 29, 2018

Two Important Reaction Patterns: Ortho- , Para- and Meta- Directors It’s one thing to learn about electrophilic aromatic substitution reactions of benzene itself. But once you move beyond benzene, that’s w…

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