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Substitution Reactions

By James Ashenhurst

Why the SN2 Reaction Is Powerful

Last updated: March 22nd, 2019 |

Having gone through the mechanism of the SN2 reaction, let’s take a second and look at why it might be useful.

In nucleophilic substitution reactions, we’re trading a carbon-(leaving group) bond for a carbon-(nucleophile) bond.

If we choose a good leaving group – i.e. an appropriately weak base – we can use this reaction with a *large* variety of nucleophiles.

The SN2 Reaction Is Incredibly Powerful And Can Be Used To Build A Large Number Of Functional Groups From Alkyl Halides

I could write many more words about this, but instead, here’s a table. Look at all the different functional groups you can make from just this one reaction!


Note – some of these substitution reactions work better than others,  especially on secondary carbons – depending on conditions, elimination reactions can start to compete when strong bases are used. We’ll get there!

Next Post – The SN1 Mechanism

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